Proof Positivity: On The Science Beat

New Diabetes Findings

“Blood glucose levels are tightly regulated by secretion of insulin from beta cells in the pancreas. Defective insulin secretion results in poorly regulated blood glucose levels and diabetes.

The work of the multi-national research team explored the role of LKB1, a gene involved in many cellular functions, whose role in the pancreas was not examined before. Specifically, they studied the implications of beta cell-specific loss of the LKB1 gene, using a mouse model system. They were able to show that eliminating this gene from beta cells causes the production and secretion of more insulin than normal beta cells, resulting in an enhanced response to increases in blood glucose levels.”

The findings would help those who have high blood sugar.  LKB1 has a negatively controls how much insulin is in your system and how much it’s secreted.  Scientists are hoping to create a therapy that would limit the presence of this gene in pancreas beta cells, a type of cell in the pancreas in areas called the islets of Langerhans which make up 65-80% of the cells in the islets, thus enhancing insulin secretion.

From Science Daily

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